Best Pill To Lose Weight Fast 2021 – Another weight loss trial for weekly GLP-1 drug gains – effective in diabetic patients with BMI less than 27
When paired with lifestyle management, once-weekly semaglutide (Ozempic) provided significant weight loss in overweight adults with type 2 diabetes, the manufacturer-sponsored Semaglutide Treatment Effectiveness in Obese People (STEP) 2 study found.
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In a superiority phase III trial of 1,200 adults with a body mass index (BMI) of at least 27, subjects with 2.4 mg weekly subcutaneous semaglutide lost an average of 9.6% of baseline body weight after 68 weeks of treatment and 3.4% with placebo and lifestyle intervention only (treatment difference -6.2 percentage points, 95% CI -7.3 to -5.2,
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The study, published online in The Lancet, also included a third treatment group of patients who received 1.0 mg of semaglutide once a week – a dose already approved for type 2 diabetes (like the 0.5 mg- dose). After 68 weeks of treatment, this group had an average reduction of 7% in baseline body weight.
By week 68, patients on 2.4 mg weekly semaglutide had at least a 5% reduction in body weight versus placebo (OR 4.88, 95% CI 3.58–6.64,
Overall, about 69% of those on 2.4 mg of semaglutide were able to lose at least 5% of their baseline body weight—in line with the trial’s other coprimary endpoint—compared to just 29% on the lifestyle intervention. 57% of subjects at the 1 mg dose achieved at least 5% weight loss.
Beyond the weight loss benefits, those taking 2.4 mg of semaglutide also saw significant improvements in waist circumference, systolic blood pressure, lipid profile, inflammatory markers and physical function, the researchers reported.
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In addition, not surprisingly, significant improvements were also seen in blood glucose, with 68% of high-dose subjects able to achieve an HbA1c of 6.5% or less, while 79% achieved a number below 7%.
These findings are based on the recently reported STEP 1 trial, which tested semaglutide in a population of adults with obesity (30+ BMI), but without type 2 diabetes.
In the same 68-week trial, adults on 2.4 mg weekly semaglutide lost an average of 14.9% of baseline body weight and only 2.4% with placebo and lifestyle intervention alone (treatment difference -12.4%, 95% CI -13.4 to -11.5,
“This is the first trial to demonstrate that once-weekly subcutaneous semaglutide 2.4 mg produces clinically meaningful reductions in body weight in adults who are overweight or obese and have type 2 diabetes,” Lingway’s team wrote. “The magnitude of weight loss achieved with semaglutide 2.4 mg in STEP 2 was greater than that seen with liraglutide and other approved anti-obesity drugs in similar patient populations.”
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Liraglutide (Saxenda) was approved in December 2014 at a dose of 3 mg/day for long-term weight management in adults with a BMI of 30 or greater or a BMI of 27 or greater and at least one weight-related medical condition.
In a commentary, Roberto Latini, MD, and Lidia Staszewski, MD, of the Mario Negri Institute of Pharmacological Research IRCCS in Milan, Italy, point to two major advantages of semaglutide dosing once a week. than once a day with liraglutide – and a stronger effect on weight loss.
The STEP 2 trial included 1,210 adults from 149 outpatient clinics in North America, Europe, South America, the Middle East, South Africa and Asia. For inclusion, all participants had to have a BMI of at least 27 and an HbA1c of 7-10% and be diagnosed with type 2 diabetes at least 180 days prior to screening.
However, patients on insulin were excluded, which Latini and Staszewski called “an issue that should be considered in future studies given the widespread use of insulin.”
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Participants were randomized in a 1:1:1 fashion – 404 received 2.4 mg of semaglutide, 403 received 1 mg of semaglutide, and 403 received placebo.
Treatment was initiated at a 0.25-mg weekly dose and titrated every 4 weeks in a fixed-dose regimen until the target dose was reached. All participants also underwent a lifestyle intervention that included 150 minutes of physical exercise per week and a 500-kcal per day deficit.
Adverse events in the STEP clinical program were generally consistent with those seen with other GLP-1 receptor agonists, with gastrointestinal side effects being the most common.
Overall, 64% of those on the high semaglutide dose experienced gastrointestinal adverse events, including nausea, vomiting, diarrhea, and constipation—most of which were mild to moderate. About a third of patients who took 1 mg of semaglutide had gastrointestinal side effects.
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In December 2020, Novo Nordisk received US approval for 2.4 mg semaglutide for long-term weight management in adults who are obese or overweight and have at least one weight-related comorbidity based on the STEP program. Submitted for marketing approval.
Source reference: Davies M, et al “Semaglutide 2·4 mg once weekly for overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial” Lancet 2021; DOI: 10.1016/S0140-6736(21)00213-0.METFORMIN EXTENDED-RELEASE RECALL In May 2020, the Food and Drug Administration (FDA) recommended that certain metformin extended-release tablets be removed from the US market. Because unacceptable levels of a potential carcinogen (cancer-causing agent) have been found in some extended-release metformin tablets. If you are currently taking this medicine, call your healthcare provider. They will advise if you should continue taking your medication or if you need a new prescription.
Metformin is a drug used by doctors to treat people with type 2 diabetes. It works with other medicines and insulin to lower blood sugar in people with the condition.
Doctors do not usually prescribe metformin for type 1 diabetes. Although this use is not approved by the Food and Drug Administration (FDA) of the United States, they can sometimes prescribe it to women with polycystic ovarian syndrome.
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Likewise, the FDA has not approved metformin to help those who are overweight or obese and want to shed pounds.
In this article we will see how metformin affects weight, as well as how the drug is used.
People with type 2 diabetes have lost weight after taking metformin, but they are not the only ones who benefit from the drug in this way.
A study of people who were overweight or obese and insulin resistant showed that they lost weight when taking metformin.
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Although some evidence suggests that metformin can lead to weight loss, neither doctors nor scientists know exactly how it works.
Some researchers believe that the drug suppresses the appetite. Others think it changes the way the body stores and uses fat.
Doctors recommend certain changes in diet and lifestyle along with metformin and medications for type 2 diabetes or prediabetes. Many of these changes in diet and lifestyle will likely lead to weight loss if the individual follows the recommendations.
Metformin alone is not enough for weight loss if a person using metformin does not adopt other healthy habits.
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The FDA has not approved metformin for weight loss purposes. However, some doctors prescribe it to people who are overweight or obese and have type 2 diabetes or prediabetes.
If metformin is prescribed for these conditions, the person must follow other healthy habits to lose weight. These habits include following a nutrient-dense, low-calorie diet and exercising regularly.
Metformin is not a quick fix, miracle diet drug. People who take metformin are more likely to lose weight gradually over a long period of time.
It should also be noted that people who lose weight while taking metformin can regain it when they stop taking the drug.
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The exact dose of metformin that people should take varies. A person should talk to their doctor about the correct dosage and report any side effects after taking the medication.
The dosage of metformin depends on the person with type 2 diabetes. How much a person takes depends on the form and brand of metformin. People can take some medications with food, some on their own, and others with insulin.
If a person misses a dose of metformin, they should try to take it as soon as possible. If they are too close to their next scheduled dose, skip the missed dose. Doubling metformin doses is not recommended.
As always, a person should talk to their doctor about the correct dosage and any changes to their medication.
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Metformin tablets have some dangerous side effects. The FDA has issued its highest warning level about metformin.
Although rare, metformin can cause lactic acidosis. Lactic acidosis is an unsafe build-up of lactic acid in the blood.
A person taking metformin should go to the emergency room for treatment immediately if they experience any of the following symptoms:
Another serious side effect is a low blood sugar response. When this happens, a person’s blood sugar drops to unsafe levels.
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Treatment for a low blood sugar reaction should be started immediately to avoid some serious side effects. The treatment involves ingestion of 15 to 20 grams (g) of glucose.
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